Rho GTPase-activating protein 19 (ARHGAP19)

About Rho GTPase-activating protein 19

Rho GTPase-activating protein 19 (ARHGAP19) is a protein from Homo sapiens identified by UniProt accession Q14CB8, 494 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Rho GTPase-activating protein 19
UniProt accession	Q14CB8
Gene	ARHGAP19
Organism	Homo sapiens
Length	494 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

body mass index · score 0.32
monocyte count · score 0.32
neutrophil count · score 0.30
leukocyte count · score 0.27
eosinophil count · score 0.25
neutrophil-to-lymphocyte ratio · score 0.21
type 2 diabetes mellitus · score 0.20
electrocardiography · score 0.18
grip strength measurement · score 0.18
lymphocyte percentage of leukocytes · score 0.18

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14CB8-F1	alphafold	PREDICTED	69.65	—

Amino-acid sequence (494 residues)

MATEAQSEGE VPARESGRSD AICSFVICND SSLRGQPIIF NPDFFVEKLR HEKPEIFTEL VVSNITRLID LPGTELAQLM GEVDLKLPGG AGPASGFFRS LMSLKRKEKG VIFGSPLTEE GIAQIYQLIE YLHKNLRVEG LFRVPGNSVR QQILRDALNN GTDIDLESGE FHSNDVATLL KMFLGELPEP LLTHKHFNAH LKIADLMQFD DKGNKTNIPD KDRQIEALQL LFLILPPPNR NLLKLLLDLL YQTAKKQDKN KMSAYNLALM FAPHVLWPKN VTANDLQENI TKLNSGMAFM IKHSQKLFKA PAYIRECARL HYLGSRTQAS KDDLDLIASC HTKSFQLAKS QKRNRVDSCP HQEETQHHTE EALRELFQHV HDMPESAKKK QLIRQFNKQS LTQTPGREPS TSQVQKRARS RSFSGLIKRK VLGNQMMSEK KKKNPTPESV AIGELKGTSK ENRNLLFSGS PAVTMTPTRL KWSEGKKEGK KGFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards