Keratin, type II cytoskeletal 72 (KRT72)

About Keratin, type II cytoskeletal 72

Keratin, type II cytoskeletal 72 (KRT72) is a protein from Homo sapiens identified by UniProt accession Q14CN4, 511 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Keratin, type II cytoskeletal 72
UniProt accession	Q14CN4
Gene	KRT72
Organism	Homo sapiens
Length	511 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.28
head and neck squamous cell carcinoma · score 0.19
ovarian cancer · score 0.18
clear cell renal carcinoma · score 0.18
breast adenocarcinoma · score 0.18
appendicitis · score 0.14
esophageal cancer · score 0.14
disorder of appendix · score 0.12
psoriasis · score 0.06
Testicular regression syndrome · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14CN4-F1	alphafold	PREDICTED	70.65	—

Amino-acid sequence (511 residues)

MSRQLTHFPR GERLGFSGCS AVLSGGIGSS SASFRARVKG SASFGSKSLS CLGGSRSLAL SAAARRGGGR LGGFVGTAFG SAGLGPKCPS VCPPGGIPQV TVNKSLLAPL NVEMDPEIQR VRAQEREQIK ALNNKFASFI DKVRFLEQQN QVLETKWNLL QQLDLNNCRK NLEPIYEGYI SNLQKQLEML SGDGVRLDSE LRNMQDLVED YKKRYEVEIN RRTAAENEFV VLKKDVDAAY MNKVELQAKV DSLTDEIKFF KCLYEGEITQ IQSHISDTSI VLSMDNNRDL DLDSIIAEVR AQYEEIALKS KAEAETLYQT KIQELQVTAG QHGDDLKLTK AEISELNRLI QRIRSEIGNV KKQCADLETA IADAEQRGDC ALKDARAKLD ELEGALHQAK EELARMLREY QELVSLKLAL DMEIATYRKL LESEECRMSG EYPNSVSISV ISSTNAGAGG AGFSMGFGAS SSYSYKTAAA DVKTKGSCGS ELKDPLAKTS GSSCATKKAS R

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards