UBX domain-containing protein 2B (UBXN2B)

About UBX domain-containing protein 2B

UBX domain-containing protein 2B (UBXN2B) is a protein from Homo sapiens identified by UniProt accession Q14CS0, 331 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	UBX domain-containing protein 2B
UniProt accession	Q14CS0
Gene	UBXN2B
Organism	Homo sapiens
Length	331 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

low density lipoprotein cholesterol measurement · score 0.34
total cholesterol measurement · score 0.31
triglyceride measurement · score 0.28
alcohol consumption measurement · score 0.28
vitamin D measurement · score 0.28
cholelithiasis · score 0.27
alcohol drinking · score 0.26
Hypercholesterolemia · score 0.25
gallstones · score 0.23
HMG CoA reductase inhibitor use measurement · score 0.22

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14CS0-F1	alphafold	PREDICTED	70.33	—

Amino-acid sequence (331 residues)

MAEGGGPEPG EQERRSSGPR PPSARDLQLA LAELYEDEVK CKSSKSNRPK ATVFKSPRTP PQRFYSSEHE YSGLNIVRPS TGKIVNELFK EAREHGAVPL NEATRASGDD KSKSFTGGGY RLGSSFCKRS EYIYGENQLQ DVQILLKLWS NGFSLDDGEL RPYNEPTNAQ FLESVKRGEI PLELQRLVHG GQVNLDMEDH QDQEYIKPRL RFKAFSGEGQ KLGSLTPEIV STPSSPEEED KSILNAVVLI DDSVPTTKIQ IRLADGSRLI QRFNSTHRIL DVRNFIVQSR PEFAALDFIL VTSFPNKELT DESLTLLEAD ILNTVLLQQL K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards