Ataxin-7-like protein 3 (ATXN7L3)

About Ataxin-7-like protein 3

Ataxin-7-like protein 3 (ATXN7L3) is a protein from Homo sapiens identified by UniProt accession Q14CW9, 347 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	Ataxin-7-like protein 3
UniProt accession	Q14CW9
Gene	ATXN7L3
Organism	Homo sapiens
Length	347 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
breast adenocarcinoma · score 0.22
hematocrit · score 0.15
reticulocyte count · score 0.11
body fat distribution · score 0.10
body fat percentage · score 0.08
calcium measurement · score 0.08
hepatocellular carcinoma · score 0.08
appendicular lean mass · score 0.07
visceral adipose tissue measurement · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14CW9-F1	alphafold	PREDICTED	65.46	—

Amino-acid sequence (347 residues)

MKMEEMSLSG LDNSKLEAIA QEIYADLVED SCLGFCFEVH RAVKCGYFFL DDTDPDSMKD FEIVDQPGLD IFGQVFNQWK SKECVCPNCS RSIAASRFAP HLEKCLGMGR NSSRIANRRI ANSNNMNKSE SDQEDNDDIN DNDWSYGSEK KAKKRKSDKN PNSPRRSKSL KHKNGELSNS DPFKYNNSTG ISYETLGPEE LRSLLTTQCG VISEHTKKMC TRSLRCPQHT DEQRRTVRIY FLGPSAVLPE VESSLDNDSF DMTDSQALIS RLQWDGSSDL SPSDSGSSKT SENQGWGLGT NSSESRKTKK KKSHLSLVGT ASGLGSNKKK KPKPPAPPTP SIYDDIN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards