About HUWE1-associated protein modifying stress responses 1
HUWE1-associated protein modifying stress responses 1 (HAPSTR1) is a protein
from Homo sapiens identified by UniProt accession
Q14CZ0, 275 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | HUWE1-associated protein modifying stress responses 1 |
|---|
| UniProt accession | Q14CZ0 |
|---|
| Gene | HAPSTR1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 275 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (42)
Diseases linked to this target (Open Targets).
- lean body mass · score 0.44
- body weight · score 0.42
- body mass index · score 0.38
- hemoglobin measurement · score 0.36
- body height · score 0.35
- hair shape measurement · score 0.33
- balding measurement · score 0.33
- insomnia measurement · score 0.31
- age at menopause · score 0.31
- Sleep Disorder · score 0.31
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q14CZ0-F1 | alphafold | PREDICTED | 69.28 | — |
Amino-acid sequence (275 residues)
MEERKEEGEA EIQEHGPEHW FSKWERQCLA EAEQDEQLPP ELQEEAAAAA QPEHKQQKLW HLFQNSATAV AQLYKDRVCQ QPGLSLWVPF QNAATAVTNL YKESVDTHQR SFDIGIQIGY QRRNKDVLAW VKKRRRTIRR EDLISFLCGK VPPPRNSRAP PRLTVVSPNR ATSTETSSSV ETDLQPFREA IALHGLSGAM ASISVRSSTP GSPTHVSSGS NASRRRNGLH DVDLNTFISE EMALHLDNGG TRKRTSAQCG DVITDSPTHK RNRMI
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