Hepatic and glial cell adhesion molecule (HEPACAM)

About Hepatic and glial cell adhesion molecule

Hepatic and glial cell adhesion molecule (HEPACAM) is a protein from Homo sapiens identified by UniProt accession Q14CZ8, 416 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.

Target properties

Protein name	Hepatic and glial cell adhesion molecule
UniProt accession	Q14CZ8
Gene	HEPACAM
Organism	Homo sapiens
Length	416 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (63)

Diseases linked to this target (Open Targets).

megalencephalic leukoencephalopathy with subcortical cysts · score 0.76
macrocephaly-autism syndrome · score 0.37
autism spectrum disorder · score 0.27
genetic disorder · score 0.19
Intellectual disability · score 0.11
hepatocellular carcinoma · score 0.07
medulloblastoma · score 0.04
urinary bladder carcinoma · score 0.04
isolated focal cortical dysplasia type II · score 0.04
leukodystrophy · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q14CZ8-F1	alphafold	PREDICTED	72.57	—

Amino-acid sequence (416 residues)

MKRERGALSR ASRALRLAPF VYLLLIQTDP LEGVNITSPV RLIHGTVGKS ALLSVQYSST SSDRPVVKWQ LKRDKPVTVV QSIGTEVIGT LRPDYRDRIR LFENGSLLLS DLQLADEGTY EVEISITDDT FTGEKTINLT VDVPISRPQV LVASTTVLEL SEAFTLNCSH ENGTKPSYTW LKDGKPLLND SRMLLSPDQK VLTITRVLME DDDLYSCMVE NPISQGRSLP VKITVYRRSS LYIILSTGGI FLLVTLVTVC ACWKPSKRKQ KKLEKQNSLE YMDQNDDRLK PEADTLPRSG EQERKNPMAL YILKDKDSPE TEENPAPEPR SATEPGPPGY SVSPAVPGRS PGLPIRSARR YPRSPARSPA TGRTHSSPPR APSSPGRSRS ASRTLRTAGV HIIREQDEAG PVEISA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards