About Condensin complex subunit 2
Condensin complex subunit 2 (NCAPH) is a protein
from Homo sapiens identified by UniProt accession
Q15003, 741 residues long.
MolForge cross-references it against 0 known binders and
85 disease associations.
Target properties
| Protein name | Condensin complex subunit 2 |
|---|
| UniProt accession | Q15003 |
|---|
| Gene | NCAPH |
|---|
| Organism | Homo sapiens |
|---|
| Length | 741 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (85)
Diseases linked to this target (Open Targets).
- autosomal recessive primary microcephaly · score 0.42
- acute myeloid leukemia · score 0.22
- eosinophil percentage of leukocytes · score 0.19
- lung adenocarcinoma · score 0.10
- neoplasm · score 0.09
- non-small cell lung carcinoma · score 0.09
- hepatocellular carcinoma · score 0.08
- oral squamous cell carcinoma · score 0.08
- nonpapillary renal cell carcinoma · score 0.07
- mathematical ability · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15003-F1 | alphafold | PREDICTED | 59.75 | — |
Amino-acid sequence (741 residues)
MGPPGPALPA TMNNSSSETR GHPHSASSPS ERVFPMPLPR KAPLNIPGTP VLEDFPQNDD EKERLQRRRS RVFDLQFSTD SPRLLASPSS RSIDISATIP KFTNTQITEH YSTCIKLSTE NKITTKNAFG LHLIDFMSEI LKQKDTEPTN FKVAAGTLDA STKIYAVRVD AVHADVYRVL GGLGKDAPSL EEVEGHVADG SATEMGTTKK AVKPKKKHLH RTIEQNINNL NVSEADRKCE IDPMFQKTAA SFDECSTAGV FLSTLHCQDY RSELLFPSDV QTLSTGEPLE LPELGCVEMT DLKAPLQQCA EDRQICPSLA GFQFTQWDSE THNESVSALV DKFKKNDQVF DINAEVDESD CGDFPDGSLG DDFDANDEPD HTAVGDHEEF RSWKEPCQVQ SCQEEMISLG DGDIRTMCPL LSMKPGEYSY FSPRTMSMWA GPDHWRFRPR RKQDAPSQSE NKKKSTKKDF EIDFEDDIDF DVYFRKTKAA TILTKSTLEN QNWRATTLPT DFNYNVDTLV QLHLKPGTRL LKMAQGHRVE TEHYEEIEDY DYNNPNDTSN FCPGLQAADS DDEDLDDLFV GPVGNSDLSP YPCHPPKTAQ QNGDTPEAQG LDITTYGESN LVAEPQKVNK IEIHYAKTAK KMDMKKLKQS MWSLLTALSG KEADAEANHR EAGKEAALAE VADEKMLSGL TKDLQRSLPP VMAQNLSIPL AFACLLHLAN EKNLKLEGTE DLSDVLVRQG D
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