PCNA-associated factor (PCLAF)

About PCNA-associated factor

PCNA-associated factor (PCLAF) is a protein from Homo sapiens identified by UniProt accession Q15004, 111 residues long. MolForge cross-references it against 0 known binders and 586 disease associations.

Target properties

Protein name	PCNA-associated factor
UniProt accession	Q15004
Gene	PCLAF
Organism	Homo sapiens
Length	111 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (586)

Diseases linked to this target (Open Targets).

neutrophil count · score 0.40
myeloid white cell count · score 0.37
leukocyte count · score 0.31
sum of neutrophil and eosinophil counts · score 0.15
granulocyte count · score 0.15
sum of basophil and neutrophil counts · score 0.13
hepatocellular carcinoma · score 0.11
monocyte count · score 0.11
non-small cell lung carcinoma · score 0.11
date of birth · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15004-F1	alphafold	PREDICTED	65.12	—

Amino-acid sequence (111 residues)

MVRTKADSVP GTYRKVVAAR APRKVLGSST SATNSTSVSS RKAENKYAGG NPVCVRPTPK WQKGIGEFFR LSPKDSEKEN QIPEEAGSSG LGKAKRKACP LQPDHTNDEK E

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards