ER membrane protein complex subunit 2 (EMC2)

About ER membrane protein complex subunit 2

ER membrane protein complex subunit 2 (EMC2) is a protein from Homo sapiens identified by UniProt accession Q15006, 297 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	ER membrane protein complex subunit 2
UniProt accession	Q15006
Gene	EMC2
Organism	Homo sapiens
Length	297 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.54
brain measurement · score 0.32
FEV/FVC ratio · score 0.27
protein measurement · score 0.27
neuroimaging measurement · score 0.26
Alzheimer disease · score 0.22
multiple sclerosis · score 0.22
lysosomal storage disease · score 0.22
Parkinson disease · score 0.22
brain volume measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15006-F1	alphafold	PREDICTED	94.28	—

Amino-acid sequence (297 residues)

MAKVSELYDV TWEEMRDKMR KWREENSRNS EQIVEVGEEL INEYASKLGD DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKNVEA IRELNEYLEQ FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPHNHL YCQQYAEVKY TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKTK KDNMKYASWA ASQINRAYQF AGRSKKETKY SLKAVEDMLE TLQITQS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards