Pre-mRNA-splicing regulator WTAP (WTAP)

About Pre-mRNA-splicing regulator WTAP

Pre-mRNA-splicing regulator WTAP (WTAP) is a protein from Homo sapiens identified by UniProt accession Q15007, 396 residues long. MolForge cross-references it against 0 known binders and 162 disease associations.

Target properties

Protein name	Pre-mRNA-splicing regulator WTAP
UniProt accession	Q15007
Gene	WTAP
Organism	Homo sapiens
Length	396 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (162)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.39
low density lipoprotein cholesterol measurement · score 0.11
hepatocellular carcinoma · score 0.10
lipoprotein A measurement · score 0.09
renal cell carcinoma · score 0.09
electrocardiography · score 0.09
QRS complex · score 0.09
QRS duration · score 0.09
Systemic lupus erythematosus · score 0.08
diffuse large B-cell lymphoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15007-F1	alphafold	PREDICTED	71.01	—

Amino-acid sequence (396 residues)

MTNEEPLPKK VRLSETDFKV MARDELILRW KQYEAYVQAL EGKYTDLNSN DVTGLRESEE KLKQQQQESA RRENILVMRL ATKEQEMQEC TTQIQYLKQV QQPSVAQLRS TMVDPAINLF FLKMKGELEQ TKDKLEQAQN ELSAWKFTPD SQTGKKLMAK CRMLIQENQE LGRQLSQGRI AQLEAELALQ KKYSEELKSS QDELNDFIIQ LDEEVEGMQS TILVLQQQLK ETRQQLAQYQ QQQSQASAPS TSRTTASEPV EQSEATSKDC SRLTNGPSNG SSSRQRTSGS GFHREGNTTE DDFPSSPGNG NKSSNSSEER TGRGGSGYVN QLSAGYESVD SPTGSENSLT HQSNDTDSSH DPQEEKAVSG KGNRTVGSRH VQNGLDSSVN VQGSVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards