26S proteasome non-ATPase regulatory subunit 6 (PSMD6)

About 26S proteasome non-ATPase regulatory subunit 6

26S proteasome non-ATPase regulatory subunit 6 (PSMD6) is a protein from Homo sapiens identified by UniProt accession Q15008, 389 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	26S proteasome non-ATPase regulatory subunit 6
UniProt accession	Q15008
Gene	PSMD6
Organism	Homo sapiens
Length	389 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

HIV infection · score 0.46
type 2 diabetes mellitus · score 0.32
breast adenocarcinoma · score 0.30
endometrial cancer · score 0.29
lung adenocarcinoma · score 0.28
clear cell renal carcinoma · score 0.27
gastric adenocarcinoma · score 0.27
neurodegenerative disease · score 0.26
mean corpuscular volume · score 0.19
mean corpuscular hemoglobin concentration · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15008-F1	alphafold	PREDICTED	82.39	—

Amino-acid sequence (389 residues)

MPLENLEEEG LPKNPDLRIA QLRFLLSLPE HRGDAAVRDE LMAAVRDNNM APYYEALCKS LDWQIDVDLL NKMKKANEDE LKRLDEELED AEKNLGESEI RDAMMAKAEY LCRIGDKEGA LTAFRKTYDK TVALGHRLDI VFYLLRIGLF YMDNDLITRN TEKAKSLIEE GGDWDRRNRL KVYQGLYCVA IRDFKQAAEL FLDTVSTFTS YELMDYKTFV TYTVYVSMIA LERPDLREKV IKGAEILEVL HSLPAVRQYL FSLYECRYSV FFQSLAVVEQ EMKKDWLFAP HYRYYVREMR IHAYSQLLES YRSLTLGYMA EAFGVGVEFI DQELSRFIAA GRLHCKIDKV NEIVETNRPD SKNWQYQETI KKGDLLLNRV QKLSRVINM

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards