About Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1) is a protein
from Homo sapiens identified by UniProt accession
Q15011, 391 residues long.
MolForge cross-references it against 0 known binders and
201 disease associations.
Target properties
| Protein name | Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein |
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| UniProt accession | Q15011 |
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| Gene | HERPUD1 |
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| Organism | Homo sapiens |
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| Length | 391 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (201)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.41
- hereditary breast ovarian cancer syndrome · score 0.34
- Hereditary breast and ovarian cancer syndrome · score 0.34
- apolipoprotein A 1 measurement · score 0.30
- Pancreatic Acinar Cell Carcinoma · score 0.28
- pancreatic ductal adenocarcinoma · score 0.28
- body height · score 0.26
- BMI-adjusted hip circumference · score 0.26
- lung adenocarcinoma · score 0.19
- urinary bladder carcinoma · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15011-F1 | alphafold | PREDICTED | 62.22 | — |
Amino-acid sequence (391 residues)
MESETEPEPV TLLVKSPNQR HRDLELSGDR GWSVGHLKAH LSRVYPERPR PEDQRLIYSG KLLLDHQCLR DLLPKQEKRH VLHLVCNVKS PSKMPEINAK VAESTEEPAG SNRGQYPEDS SSDGLRQREV LRNLSSPGWE NISRPEAAQQ AFQGLGPGFS GYTPYGWLQL SWFQQIYARQ YYMQYLAATA ASGAFVPPPS AQEIPVVSAP APAPIHNQFP AENQPANQNA APQVVVNPGA NQNLRMNAQG GPIVEEDDEI NRDWLDWTYS AATFSVFLSI LYFYSSLSRF LMVMGATVVM YLHHVGWFPF RPRPVQNFPN DGPPPDVVNQ DPNNNLQEGT DPETEDPNHL PPDRDVLDGE QTSPSFMSTA WLVFKTFFAS LLPEGPPAIA N
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