Lysosomal-associated transmembrane protein 4A…

About Lysosomal-associated transmembrane protein 4A

Lysosomal-associated transmembrane protein 4A (LAPTM4A) is a protein from Homo sapiens identified by UniProt accession Q15012, 233 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	Lysosomal-associated transmembrane protein 4A
UniProt accession	Q15012
Gene	LAPTM4A
Organism	Homo sapiens
Length	233 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

testosterone measurement · score 0.34
blood protein measurement · score 0.32
heel bone mineral density · score 0.08
hemoglobin measurement · score 0.08
bone quantitative ultrasound measurement · score 0.05
glioblastoma multiforme · score 0.05
cancer · score 0.05
Brugada syndrome · score 0.05
Romano-Ward syndrome · score 0.05
Arrhythmogenic right ventricular dysplasia · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15012-F1	alphafold	PREDICTED	72.37	—

Amino-acid sequence (233 residues)

MVSMSFKRNR SDRFYSTRCC GCCHVRTGTI ILGTWYMVVN LLMAILLTVE VTHPNSMPAV NIQYEVIGNY YSSERMADNA CVLFAVSVLM FIISSMLVYG AISYQVGWLI PFFCYRLFDF VLSCLVAISS LTYLPRIKEY LDQLPDFPYK DDLLALDSSC LLFIVLVFFA LFIIFKAYLI NCVWNCYKYI NNRNVPEIAV YPAFEAPPQY VLPTYEMAVK MPEKEPPPPY LPA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Lysosomal-associated transmembrane protein 4A (LAPTM4A)