About Exosome complex component RRP42
Exosome complex component RRP42 (EXOSC7) is a protein
from Homo sapiens identified by UniProt accession
Q15024, 291 residues long.
MolForge cross-references it against 0 known binders and
12 disease associations.
Target properties
| Protein name | Exosome complex component RRP42 |
|---|
| UniProt accession | Q15024 |
|---|
| Gene | EXOSC7 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 291 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (12)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- blood protein measurement · score 0.11
- breast adenocarcinoma · score 0.10
- PHF-tau measurement · score 0.08
- t-tau:beta-amyloid 1-42 ratio measurement · score 0.02
- COVID-19 · score 0.00
- gestational diabetes · score 0.00
- Intestinal epithelial dysplasia · score 0.00
- Mantle cell lymphoma · score 0.00
- Stroke · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15024-F1 | alphafold | PREDICTED | 84.28 | — |
Amino-acid sequence (291 residues)
MASVTLSEAE KVYIVHGVQE DLRVDGRGCE DYRCVEVETD VVSNTSGSAR VKLGHTDILV GVKAEMGTPK LEKPNEGYLE FFVDCSASAT PEFEGRGGDD LGTEIANTLY RIFNNKSSVD LKTLCISPRE HCWVLYVDVL LLECGGNLFD AISIAVKAAL FNTRIPRVRV LEDEEGSKDI ELSDDPYDCI RLSVENVPCI VTLCKIGYRH VVDATLQEEA CSLASLLVSV TSKGVVTCMR KVGKGSLDPE SIFEMMETGK RVGKVLHASL QSVVHKEESL GPKRQKVGFL G
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