About Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 (ACAP1) is a protein
from Homo sapiens identified by UniProt accession
Q15027, 740 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 |
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| UniProt accession | Q15027 |
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| Gene | ACAP1 |
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| Organism | Homo sapiens |
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| Length | 740 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- hypothyroidism · score 0.30
- neutrophil count · score 0.28
- thyroid disease · score 0.26
- Hashimoto's thyroiditis · score 0.26
- myeloid white cell count · score 0.25
- leukocyte count · score 0.24
- systemic lupus erythematosus · score 0.24
- lymphocyte count · score 0.23
- monocyte percentage of leukocytes · score 0.21
- autoimmune thyroid disease · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15027-F1 | alphafold | PREDICTED | 84.35 | — |
Amino-acid sequence (740 residues)
MTVKLDFEEC LKDSPRFRAS IELVEAEVSE LETRLEKLLK LGTGLLESGR HYLAASRAFV VGICDLARLG PPEPMMAECL EKFTVSLNHK LDSHAELLDA TQHTLQQQIQ TLVKEGLRGF REARRDFWRG AESLEAALTH NAEVPRRRAQ EAEEAGAALR TARAGYRGRA LDYALQINVI EDKRKFDIME FVLRLVEAQA THFQQGHEEL SRLSQYRKEL GAQLHQLVLN SAREKRDMEQ RHVLLKQKEL GGEEPEPSLR EGPGGLVMEG HLFKRASNAF KTWSRRWFTI QSNQLVYQKK YKDPVTVVVD DLRLCTVKLC PDSERRFCFE VVSTSKSCLL QADSERLLQL WVSAVQSSIA SAFSQARLDD SPRGPGQGSG HLAIGSAATL GSGGMARGRE PGGVGHVVAQ VQSVDGNAQC CDCREPAPEW ASINLGVTLC IQCSGIHRSL GVHFSKVRSL TLDSWEPELV KLMCELGNVI INQIYEARVE AMAVKKPGPS CSRQEKEAWI HAKYVEKKFL TKLPEIRGRR GGRGRPRGQP PVPPKPSIRP RPGSLRSKPE PPSEDLGSLH PGALLFRASG HPPSLPTMAD ALAHGADVNW VNGGQDNATP LIQATAANSL LACEFLLQNG ANVNQADSAG RGPLHHATIL GHTGLACLFL KRGADLGARD SEGRDPLTIA METANADIVT LLRLAKMREA EAAQGQAGDE TYLDIFRDFS LMASDDPEKL SRRSHDLHTL
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