About Leucine--tRNA ligase, mitochondrial
Leucine--tRNA ligase, mitochondrial (LARS2) is a protein
from Homo sapiens identified by UniProt accession
Q15031, 903 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Leucine--tRNA ligase, mitochondrial |
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| UniProt accession | Q15031 |
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| Gene | LARS2 |
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| Organism | Homo sapiens |
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| Length | 903 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (111)
Diseases linked to this target (Open Targets).
- Perrault syndrome 4 · score 0.76
- hydrops-lactic acidosis-sideroblastic anemia-multisystemic failure syndrome · score 0.75
- Perrault syndrome · score 0.56
- neurodegenerative disease · score 0.55
- Mitochondrial myopathy and sideroblastic anemia · score 0.50
- nonsyndromic genetic hearing loss · score 0.43
- autosomal dominant nonsyndromic hearing loss · score 0.43
- leukodystrophy · score 0.42
- Rare genetic deafness · score 0.41
- Perrault syndrome 2 · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15031-F1 | alphafold | PREDICTED | 90.48 | — |
Amino-acid sequence (903 residues)
MASVWQRLGF YASLLKRQLN GGPDVIKWER RVIPGCTRSI YSATGKWTKE YTLQTRKDVE KWWHQRIKEQ ASKISEADKS KPKFYVLSMF PYPSGKLHMG HVRVYTISDT IARFQKMRGM QVINPMGWDA FGLPAENAAV ERNLHPQSWT QSNIKHMRKQ LDRLGLCFSW DREITTCLPD YYKWTQYLFI KLYEAGLAYQ KEALVNWDPV DQTVLANEQV DEHGCSWRSG AKVEQKYLRQ WFIKTTAYAK AMQDALADLP EWYGIKGMQA HWIGDCVGCH LDFTLKVHGQ ATGEKLTAYT ATPEAIYGTS HVAISPSHRL LHGHSSLKEA LRMALVPGKD CLTPVMAVNM LTQQEVPVVI LAKADLEGSL DSKIGIPSTS SEDTILAQTL GLAYSEVIET LPDGTERLSS SAEFTGMTRQ DAFLALTQKA RGKRVGGDVT SDKLKDWLIS RQRYWGTPIP IVHCPVCGPT PVPLEDLPVT LPNIASFTGK GGPPLAMASE WVNCSCPRCK GAAKRETDTM DTFVDSAWYY FRYTDPHNPH SPFNTAVADY WMPVDLYIGG KEHAVMHLFY ARFFSHFCHD QKMVKHREPF HKLLAQGLIK GQTFRLPSGQ YLQREEVDLT GSVPVHAKTK EKLEVTWEKM SKSKHNGVDP EEVVEQYGID TIRLYILFAA PPEKDILWDV KTDALPGVLR WQQRLWTLTT RFIEARASGK SPQPQLLSNK EKAEARKLWE YKNSVISQVT THFTEDFSLN SAISQLMGLS NALSQASQSV ILHSPEFEDA LCALMVMAAP LAPHVTSEIW AGLALVPRKL CAHYTWDASV LLQAWPAVDP EFLQQPEVVQ MAVLINNKAC GKIPVPQQVA RDQDKVHEFV LQSELGVRLL QGRSIKKSFL SPRTALINFL VQD
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