About Translocating chain-associated membrane protein 2
Translocating chain-associated membrane protein 2 (TRAM2) is a protein
from Homo sapiens identified by UniProt accession
Q15035, 370 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Target properties
| Protein name | Translocating chain-associated membrane protein 2 |
|---|
| UniProt accession | Q15035 |
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| Gene | TRAM2 |
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| Organism | Homo sapiens |
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| Length | 370 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (132)
Diseases linked to this target (Open Targets).
- body fat percentage · score 0.46
- low density lipoprotein cholesterol measurement · score 0.40
- high density lipoprotein cholesterol measurement · score 0.39
- sex hormone-binding globulin measurement · score 0.39
- total cholesterol measurement · score 0.34
- serum alanine aminotransferase measurement · score 0.32
- low density lipoprotein triglyceride measurement · score 0.32
- aspartate aminotransferase measurement · score 0.32
- body height · score 0.32
- apolipoprotein B measurement · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15035-F1 | alphafold | PREDICTED | 85.75 | — |
Amino-acid sequence (370 residues)
MAFRRRTKSY PLFSQEFVIH NHADIGFCLV LCVLIGLMFE VTAKTAFLFI LPQYNISVPT ADSETVHYHY GPKDLVTILF YIFITIILHA VVQEYILDKI SKRLHLSKVK HSKFNESGQL VVFHFTSVIW CFYVVVTEGY LTNPRSLWED YPHVHLPFQV KFFYLCQLAY WLHALPELYF QKVRKEEIPR QLQYICLYLV HIAGAYLLNL SRLGLILLLL QYSTEFLFHT ARLFYFADEN NEKLFSAWAA VFGVTRLFIL TLAVLAIGFG LARMENQAFD PEKGNFNTLF CRLCVLLLVC AAQAWLMWRF IHSQLRHWRE YWNEQSAKRR VPATPRLPAR LIKRESGYHE NGVVKAENGT SPRTKKLKSP
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