About Josephin-1
Josephin-1 (JOSD1) is a protein
from Homo sapiens identified by UniProt accession
Q15040, 202 residues long.
MolForge cross-references it against 0 known binders and
66 disease associations.
Target properties
| Protein name | Josephin-1 |
|---|
| UniProt accession | Q15040 |
|---|
| Gene | JOSD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 202 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (66)
Diseases linked to this target (Open Targets).
- C-reactive protein measurement · score 0.27
- pancreatic adenocarcinoma · score 0.24
- serum gamma-glutamyl transferase measurement · score 0.23
- IGF-1 measurement · score 0.20
- ovarian cancer · score 0.18
- apolipoprotein A 1 measurement · score 0.15
- high density lipoprotein cholesterol measurement · score 0.13
- platelet count · score 0.11
- calcium measurement · score 0.11
- insulin like growth factor measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15040-F1 | alphafold | PREDICTED | 84.87 | — |
Amino-acid sequence (202 residues)
MSCVPWKGDK AKSESLELPQ AAPPQIYHEK QRRELCALHA LNNVFQDSNA FTRDTLQEIF QRLSPNTMVT PHKKSMLGNG NYDVNVIMAA LQTKGYEAVW WDKRRDVGVI ALTNVMGFIM NLPSSLCWGP LKLPLKRQHW ICVREVGGAY YNLDSKLKMP EWIGGESELR KFLKHHLRGK NCELLLVVPE EVEAHQSWRT DV
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