Metal cation symporter ZIP14 (SLC39A14)

About Metal cation symporter ZIP14

Metal cation symporter ZIP14 (SLC39A14) is a protein from Homo sapiens identified by UniProt accession Q15043, 492 residues long. MolForge cross-references it against 0 known binders and 278 disease associations.

Target properties

Protein name	Metal cation symporter ZIP14
UniProt accession	Q15043
Gene	SLC39A14
Organism	Homo sapiens
Length	492 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (278)

Diseases linked to this target (Open Targets).

hypermanganesemia with dystonia 2 · score 0.77
hyperostosis cranialis interna · score 0.47
genetic disorder · score 0.34
systolic blood pressure · score 0.17
mean arterial pressure · score 0.17
body height · score 0.10
B-type natriuretic peptide to N-terminal pro B-type natriuretic peptide ratio · score 0.09
polycystic ovary syndrome · score 0.07
cancer · score 0.07
renal cell carcinoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15043-F1	alphafold	PREDICTED	73.60	—

Amino-acid sequence (492 residues)

MKLLLLHPAF QSCLLLTLLG LWRTTPEAHA SSLGAPAISA ASFLQDLIHR YGEGDSLTLQ QLKALLNHLD VGVGRGNVTQ HVQGHRNLST CFSSGDLFTA HNFSEQSRIG SSELQEFCPT ILQQLDSRAC TSENQENEEN EQTEEGRPSA VEVWGYGLLC VTVISLCSLL GASVVPFMKK TFYKRLLLYF IALAIGTLYS NALFQLIPEA FGFNPLEDYY VSKSAVVFGG FYLFFFTEKI LKILLKQKNE HHHGHSHYAS ESLPSKKDQE EGVMEKLQNG DLDHMIPQHC SSELDGKAPM VDEKVIVGSL SVQDLQASQS ACYWLKGVRY SDIGTLAWMI TLSDGLHNFI DGLAIGASFT VSVFQGISTS VAILCEEFPH ELGDFVILLN AGMSIQQALF FNFLSACCCY LGLAFGILAG SHFSANWIFA LAGGMFLYIS LADMFPEMNE VCQEDERKGS ILIPFIIQNL GLLTGFTIMV VLTMYSGQIQ IG

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards