About Leucine-rich repeat-containing protein 14
Leucine-rich repeat-containing protein 14 (LRRC14) is a protein
from Homo sapiens identified by UniProt accession
Q15048, 493 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Leucine-rich repeat-containing protein 14 |
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| UniProt accession | Q15048 |
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| Gene | LRRC14 |
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| Organism | Homo sapiens |
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| Length | 493 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- Red cell distribution width · score 0.21
- intelligence · score 0.13
- self reported educational attainment · score 0.10
- cognitive function measurement · score 0.09
- type 2 diabetes mellitus · score 0.09
- mean corpuscular hemoglobin concentration · score 0.07
- blood metabolite measurement · score 0.05
- smoking status measurement · score 0.04
- testosterone measurement · score 0.04
- serum alanine aminotransferase measurement · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15048-F1 | alphafold | PREDICTED | 87.37 | — |
Amino-acid sequence (493 residues)
MHTLVFLSTR QVLQCQPAAC QALPLLPREL FPLLFKVAFM DKKTVVLREL VHTWPFPLLS FQQLLQECAH CSRALLQERP STESMQAVIL GLTARLHTSE PGASTQPLCR KHALRVLDMT GLLDDGVEQD PGTMSMWDCT AAVARTCIAQ QQGGAAEPGP APIPVEVRVD LRVNRASYAF LREALRSSVG SPLRLCCRDL RAEDLPMRNT VALLQLLDAG CLRRVDLRFN NLGLRGLSVI IPHVARFQHL ASLRLHYVHG DSRQPSVDGE DNFRYFLAQM GRFTCLRELS MGSSLLSGRL DQLLSTLQSP LESLELAFCA LLPEDLRFLA RSPHAAHLKK LDLSGNDLSG SQLAPFQGLL QASAATLLHL ELTECQLADT QLLATLPILT QCASLRYLGL YGNPLSMAGL KELLRDSVAQ AELRTVVHPF PVDCYEGLPW PPPASVLLEA SINEEKFARV EAELHQLLLA SGRAHVLWTT DIYGRLAADY FSL
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