Membrane protein MLC1 (MLC1)

About Membrane protein MLC1

Membrane protein MLC1 (MLC1) is a protein from Homo sapiens identified by UniProt accession Q15049, 377 residues long. MolForge cross-references it against 0 known binders and 201 disease associations.

Target properties

Protein name	Membrane protein MLC1
UniProt accession	Q15049
Gene	MLC1
Organism	Homo sapiens
Length	377 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (201)

Diseases linked to this target (Open Targets).

megalencephalic leukoencephalopathy with subcortical cysts · score 0.73
genetic disorder · score 0.41
Bilateral tonic-clonic seizure · score 0.37
Focal-onset seizure · score 0.37
Abnormality of the nervous system · score 0.34
CNS demyelination · score 0.27
cerebellar ataxia · score 0.27
Macrocephaly · score 0.27
plasminogen activator inhibitor 1 measurement · score 0.20
Hernia · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15049-F1	alphafold	PREDICTED	71.80	—

Amino-acid sequence (377 residues)

MTQEPFREEL AYDRMPTLER GRQDPASYAP DAKPSDLQLS KRLPPCFSHK TWVFSVLMGS CLLVTSGFSL YLGNVFPAEM DYLRCAAGSC IPSAIVSFTV SRRNANVIPN FQILFVSTFA VTTTCLIWFG CKLVLNPSAI NINFNLILLL LLELLMAATV IIAARSSEED CKKKKGSMSD SANILDEVPF PARVLKSYSV VEVIAGISAV LGGIIALNVD DSVSGPHLSV TFFWILVACF PSAIASHVAA ECPSKCLVEV LIAISSLTSP LLFTASGYLS FSIMRIVEMF KDYPPAIKPS YDVLLLLLLL VLLLQAGLNT GTAIQCVRFK VSARLQGASW DTQNGPQERL AGEVARSPLK EFDKEKAWRA VVVQMAQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards