Ribosome biogenesis regulatory protein homolog (RRS1)

About Ribosome biogenesis regulatory protein homolog

Ribosome biogenesis regulatory protein homolog (RRS1) is a protein from Homo sapiens identified by UniProt accession Q15050, 365 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.

Target properties

Protein name	Ribosome biogenesis regulatory protein homolog
UniProt accession	Q15050
Gene	RRS1
Organism	Homo sapiens
Length	365 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (54)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.47
body mass index · score 0.23
body weight · score 0.15
body height · score 0.15
PHF-tau measurement · score 0.15
waist circumference · score 0.14
breast cancer · score 0.10
hepatocellular carcinoma · score 0.10
cancer · score 0.09
retinoblastoma · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15050-F1	alphafold	PREDICTED	77.21	—

Amino-acid sequence (365 residues)

MEGQSVEELL AKAEQDEAEK LQRITVHKEL ELQFDLGNLL ASDRNPPTGL RCAGPTPEAE LQALARDNTQ LLINQLWQLP TERVEEAIVA RLPEPTTRLP REKPLPRPRP LTRWQQFARL KGIRPKKKTN LVWDEVSGQW RRRWGYQRAR DDTKEWLIEV PGNADPLEDQ FAKRIQAKKE RVAKNELNRL RNLARAHKMQ LPSAAGLHPT GHQSKEELGR AMQVAKVSTA SVGRFQERLP KEKVPRGSGK KRKFQPLFGD FAAEKKNQLE LLRVMNSKKP QLDVTRATNK QMREEDQEEA AKRRKMSQKG KRKGGRQGPG GKRKGGPPSQ GGKRKGGLGG KMNSGPPGLG GKRKGGQRPG GKRRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards