About IQ calmodulin-binding motif-containing protein 1
IQ calmodulin-binding motif-containing protein 1 (IQCB1) is a protein
from Homo sapiens identified by UniProt accession
Q15051, 598 residues long.
MolForge cross-references it against 0 known binders and
58 disease associations.
Target properties
| Protein name | IQ calmodulin-binding motif-containing protein 1 |
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| UniProt accession | Q15051 |
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| Gene | IQCB1 |
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| Organism | Homo sapiens |
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| Length | 598 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (58)
Diseases linked to this target (Open Targets).
- Senior-Loken syndrome · score 0.76
- Leber congenital amaurosis · score 0.66
- nephronophthisis · score 0.55
- Retinal dystrophy · score 0.52
- genetic disorder · score 0.41
- retinitis pigmentosa · score 0.33
- Bardet-Biedl syndrome · score 0.27
- multiple sclerosis · score 0.26
- Leber congenital amaurosis 10 · score 0.18
- Red cell distribution width · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15051-F1 | alphafold | PREDICTED | 82.80 | — |
Amino-acid sequence (598 residues)
MKPTGTDPRI LSIAAEVAKS PEQNVPVILL KLKEIINITP LGSSELKKIK QDIYCYDLIQ YCLLVLSQDY SRIQGGWTTI SQLTQILSHC CVGLEPGEDA EEFYNELLPS AAENFLVLGR QLQTCFINAA KAEEKDELLH FFQIVTDSLF WLLGGHVELI QNVLQSDHFL HLLQADNVQI GSAVMMMLQN ILQINSGDLL RIGRKALYSI LDEVIFKLFS TPSPVIRSTA TKLLLLMAES HQEILILLRQ STCYKGLRRL LSKQETGTEF SQELRQLVGL LSPMVYQEVE EQKLHQAACL IQAYWKGFQT RKRLKKLPSA VIALQRSFRS KRSKMLLEIN RQKEEEDLKL QLQLQRQRAM RLSRELQLSM LEIVHPGQVE KHYREMEEKS ALIIQKHWRG YRERKNFHQQ RQSLIEYKAA VTLQRAALKF LAKCRKKKKL FAPWRGLQEL TDARRVELKK RVDDYVRRHL GSPMSDVVSR ELHAQAQERL QHYFMGRALE ERAQQHREAL IAQISTNVEQ LMKAPSLKEA EGKEPELFLS RSRPVAAKAK QAHLTTLKHI QAPWWKKLGE ESGDEIDVPK DELSIELENL FIGGTKPP
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