About Rho guanine nucleotide exchange factor 6
Rho guanine nucleotide exchange factor 6 (ARHGEF6) is a protein
from Homo sapiens identified by UniProt accession
Q15052, 776 residues long.
MolForge cross-references it against 0 known binders and
174 disease associations.
Target properties
| Protein name | Rho guanine nucleotide exchange factor 6 |
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| UniProt accession | Q15052 |
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| Gene | ARHGEF6 |
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| Organism | Homo sapiens |
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| Length | 776 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (174)
Diseases linked to this target (Open Targets).
- X-linked non-syndromic intellectual disability · score 0.41
- breast adenocarcinoma · score 0.25
- thyroid gland adenocarcinoma · score 0.22
- glioblastoma multiforme · score 0.19
- endometrial cancer · score 0.18
- non-syndromic X-linked intellectual disability · score 0.16
- CACH syndrome · score 0.12
- head and neck squamous cell carcinoma · score 0.10
- acute myeloid leukemia · score 0.08
- lung adenocarcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15052-F1 | alphafold | PREDICTED | 71.10 | — |
Amino-acid sequence (776 residues)
MNPEEQIVTW LISLGVLESP KKTICDPEEF LKSSLKNGVV LCKLINRLMP GSVEKFCLDP QTEADCINNI NDFLKGCATL QVEIFDPDDL YSGVNFSKVL STLLAVNKAT EDQLSERPCG RSSSLSAANT SQTNPQGAVS STVSGLQRQS KTVEMTENGS HQLIVKARFN FKQTNEDELS VCKGDIIYVT RVEEGGWWEG TLNGRTGWFP SNYVREIKSS ERPLSPKAVK GFETAPLTKN YYTVVLQNIL DTEKEYAKEL QSLLVTYLRP LQSNNNLSTV EVTSLLGNFE EVCTFQQTLC QALEECSKFP ENQHKVGGCL LSLMPHFKSM YLAYCANHPS AVNVLTQHSD ELEQFMENQG ASSPGILILT TNLSKPFMRL EKYVTLLQEL ERHMEDTHPD HQDILKAIVA FKTLMGQCQD LRKRKQLELQ ILSEPIQAWE GEDIKNLGNV IFMSQVMVQY GACEEKEERY LMLFSNVLIM LSASPRMSGF IYQGKIPIAG TVVTRLDEIE GNDCTFEITG NTVERIVVHC NNNQDFQEWL EQLNRLIRGP ASCSSLSKTS SSSCSAHSSF SSTGQPRGPL EPPQIIKPWS LSCLRPAPPL RPSAALGYKE RMSYILKESS KSPKTMKKFL HKRKTERKPS EEEYVIRKST AALEEDAQIL KVIEAYCTSA NFQQGHGSST RKDSIPQVLL PEEEKLIIEE TRSNGQTIME EKSLVDTVYA LKDEVRELKQ ENKRMKQCLE EELKSRRDLE KLVRRLLKQT DECIRGESSS KTSILP
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