DNA polymerase delta subunit 3 (POLD3)

About DNA polymerase delta subunit 3

DNA polymerase delta subunit 3 (POLD3) is a protein from Homo sapiens identified by UniProt accession Q15054, 466 residues long. MolForge cross-references it against 0 known binders and 368 disease associations.

Target properties

Protein name	DNA polymerase delta subunit 3
UniProt accession	Q15054
Gene	POLD3
Organism	Homo sapiens
Length	466 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (368)

Diseases linked to this target (Open Targets).

non-small cell lung carcinoma · score 0.60
acute myeloid leukemia · score 0.60
acute lymphoblastic leukemia · score 0.60
ovarian cancer · score 0.60
pancreatic carcinoma · score 0.59
chronic lymphocytic leukemia · score 0.59
ovarian carcinoma · score 0.57
breast carcinoma · score 0.57
adult acute lymphoblastic leukemia · score 0.56
leukemia · score 0.56

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15054-F1	alphafold	PREDICTED	63.09	—

Amino-acid sequence (466 residues)

MADQLYLENI DEFVTDQNKI VTYKWLSYTL GVHVNQAKQM LYDYVERKRK ENSGAQLHVT YLVSGSLIQN GHSCHKVAVV REDKLEAVKS KLAVTASIHV YSIQKAMLKD SGPLFNTDYD ILKSNLQNCS KFSAIQCAAA VPRAPAESSS SSKKFEQSHL HMSSETQANN ELTTNGHGPP ASKQVSQQPK GIMGMFASKA AAKTQETNKE TKTEAKEVTN ASAAGNKAPG KGNMMSNFFG KAAMNKFKVN LDSEQAVKEE KIVEQPTVSV TEPKLATPAG LKKSSKKAEP VKVLQKEKKR GKRVALSDDE TKETENMRKK RRRIKLPESD SSEDEVFPDS PGAYEAESPS PPPPPSPPLE PVPKTEPEPP SVKSSSGENK RKRKRVLKSK TYLDGEGCIV TEKVYESESC TDSEEELNMK TSSVHRPPAM TVKKEPREER KGPKKGTAAL GKANRQVSIT GFFQRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards