Eukaryotic translation initiation factor 4H (EIF4H)

About Eukaryotic translation initiation factor 4H

Eukaryotic translation initiation factor 4H (EIF4H) is a protein from Homo sapiens identified by UniProt accession Q15056, 248 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Eukaryotic translation initiation factor 4H
UniProt accession	Q15056
Gene	EIF4H
Organism	Homo sapiens
Length	248 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
neoplasm · score 0.07
lung adenocarcinoma · score 0.07
X-linked retinal dysplasia · score 0.07
age-related macular degeneration · score 0.07
Familial exudative vitreoretinopathy · score 0.06
choroidal dystrophy, central areolar, 1 · score 0.06
severe early-childhood-onset retinal dystrophy · score 0.05
familial retinal arterial macroaneurysm · score 0.05
blood protein measurement · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15056-F1	alphafold	PREDICTED	60.50	—

Amino-acid sequence (248 residues)

MADFDTYDDR AYSSFGGGRG SRGSAGGHGS RSQKELPTEP PYTAYVGNLP FNTVQGDIDA IFKDLSIRSV RLVRDKDTDK FKGFCYVEFD EVDSLKEALT YDGALLGDRS LRVDIAEGRK QDKGGFGFRK GGPDDRGMGS SRESRGGWDS RDDFNSGFRD DFLGGRGGSR PGDRRTGPPM GSRFRDGPPL RGSNMDFREP TEEERAQRPR LQLKPRTVAT PLNQVANPNS AIFGGARPRE EVVQKEQE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards