About Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 (ACAP2) is a protein
from Homo sapiens identified by UniProt accession
Q15057, 778 residues long.
MolForge cross-references it against 0 known binders and
36 disease associations.
Target properties
| Protein name | Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2 |
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| UniProt accession | Q15057 |
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| Gene | ACAP2 |
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| Organism | Homo sapiens |
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| Length | 778 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (36)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- lymphocyte count · score 0.42
- reticulocyte count · score 0.42
- mean platelet volume · score 0.40
- reticulocyte measurement · score 0.36
- lymphocyte percentage of leukocytes · score 0.29
- 3-hydroxy-1-methylpropylmercapturic acid measurement · score 0.28
- body height · score 0.23
- blood protein measurement · score 0.21
- body fat percentage · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15057-F1 | alphafold | PREDICTED | 81.39 | — |
Amino-acid sequence (778 residues)
MKMTVDFEEC LKDSPRFRAA LEEVEGDVAE LELKLDKLVK LCIAMIDTGK AFCVANKQFM NGIRDLAQYS SNDAVVETSL TKFSDSLQEM INFHTILFDQ TQRSIKAQLQ NFVKEDLRKF KDAKKQFEKV SEEKENALVK NAQVQRNKQH EVEEATNILT ATRKCFRHIA LDYVLQINVL QSKRRSEILK SMLSFMYAHL AFFHQGYDLF SELGPYMKDL GAQLDRLVVD AAKEKREMEQ KHSTIQQKDF SSDDSKLEYN VDAANGIVME GYLFKRASNA FKTWNRRWFS IQNNQLVYQK KFKDNPTVVV EDLRLCTVKH CEDIERRFCF EVVSPTKSCM LQADSEKLRQ AWIKAVQTSI ATAYREKGDE SEKLDKKSSP STGSLDSGNE SKEKLLKGES ALQRVQCIPG NASCCDCGLA DPRWASINLG ITLCIECSGI HRSLGVHFSK VRSLTLDTWE PELLKLMCEL GNDVINRVYE ANVEKMGIKK PQPGQRQEKE AYIRAKYVER KFVDKYSISL SPPEQQKKFV SKSSEEKRLS ISKFGPGDQV RASAQSSVRS NDSGIQQSSD DGRESLPSTV SANSLYEPEG ERQDSSMFLD SKHLNPGLQL YRASYEKNLP KMAEALAHGA DVNWANSEEN KATPLIQAVL GGSLVTCEFL LQNGANVNQR DVQGRGPLHH ATVLGHTGQV CLFLKRGANQ HATDEEGKDP LSIAVEAANA DIVTLLRLAR MNEEMRESEG LYGQPGDETY QDIFRDFSQM ASNNPEKLNR FQQDSQKF
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