About WD repeat-containing protein 43
WD repeat-containing protein 43 (WDR43) is a protein
from Homo sapiens identified by UniProt accession
Q15061, 677 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | WD repeat-containing protein 43 |
|---|
| UniProt accession | Q15061 |
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| Gene | WDR43 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 677 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- HbA1c measurement · score 0.25
- urate measurement · score 0.25
- breast carcinoma · score 0.21
- estrogen-receptor negative breast cancer · score 0.21
- ferritin measurement · score 0.21
- neurodegenerative disease · score 0.12
- endometrial cancer · score 0.10
- cataract · score 0.08
- hemoglobin measurement · score 0.07
- self reported educational attainment · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15061-F1 | alphafold | PREDICTED | 69.62 | — |
Amino-acid sequence (677 residues)
MAAGGGGSCD PLAPAGVPCA FSPHSQAYFA LASTDGHLRV WETANNRLHQ EYVPSAHLSG TCTCLAWAPA RLQAKESPQR KKRKSEAVGM SNQTDLLALG TAVGSILLYS TVKGELHSKL ISGGHDNRVN CIQWHQDSGC LYSCSDDKHI VEWNVQTCKV KCKWKGDNSS VSSLCISPDG KMLLSAGRTI KLWVLETKEV YRHFTGHATP VSSLMFTTIR PPNESQPFDG ITGLYFLSGA VHDRLLNVWQ VRSENKEKSA VMSFTVTDEP VYIDLTLSEN KEEPVKLAVV CRDGQVHLFE HILNGYCKKP LTSNCTIQIA TPGKGKKSTP KPIPILAAGF CSDKMSLLLV YGSWFQPTIE RVALNSREPH MCLVRDISNC WAPKVETAIT KVRTPVMNSE AKVLVPGIPG HHAAIKPAPP QTEQVESKRK SGGNEVSIEE RLGAMDIDTH KKGKEDLQTN SFPVLLTQGL ESNDFEMLNK VLQTRNVNLI KKTVLRMPLH TIIPLLQELT KRLQGHPNSA VLMVQWLKCV LTVHASYLST LPDLVPQLGT LYQLMESRVK TFQKLSHLHG KLILLITQVT ASEKTKGATS PGQKAKLVYE EESSEEESDD EIADKDSEDN WDEDEEESES EKDEDVEEED EDAEGKDEEN GEDRDTASEK ELNGDSDLDP ENESEEE
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