About Peroxisomal acyl-coenzyme A oxidase 1
Peroxisomal acyl-coenzyme A oxidase 1 (ACOX1) is a protein
from Homo sapiens identified by UniProt accession
Q15067, 660 residues long.
MolForge cross-references it against 0 known binders and
308 disease associations.
Target properties
| Protein name | Peroxisomal acyl-coenzyme A oxidase 1 |
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| UniProt accession | Q15067 |
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| Gene | ACOX1 |
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| Organism | Homo sapiens |
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| Length | 660 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (308)
Diseases linked to this target (Open Targets).
- peroxisomal acyl-CoA oxidase deficiency · score 0.81
- Mitchell syndrome · score 0.76
- genetic disorder · score 0.41
- neurodegenerative disease · score 0.37
- neuroinflammatory disorder · score 0.34
- Muscle weakness · score 0.27
- urinary metabolite measurement · score 0.18
- systolic blood pressure · score 0.17
- pulse pressure measurement · score 0.16
- white matter hyperintensity measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15067-F1 | alphafold | PREDICTED | 94.04 | — |
Amino-acid sequence (660 residues)
MNPDLRRERD SASFNPELLT HILDGSPEKT RRRREIENMI LNDPDFQHED LNFLTRSQRY EVAVRKSAIM VKKMREFGIA DPDEIMWFKK LHLVNFVEPV GLNYSMFIPT LLNQGTTAQK EKWLLSSKGL QIIGTYAQTE MGHGTHLRGL ETTATYDPET QEFILNSPTV TSIKWWPGGL GKTSNHAIVL AQLITKGKCY GLHAFIVPIR EIGTHKPLPG ITVGDIGPKF GYDEIDNGYL KMDNHRIPRE NMLMKYAQVK PDGTYVKPLS NKLTYGTMVF VRSFLVGEAA RALSKACTIA IRYSAVRHQS EIKPGEPEPQ ILDFQTQQYK LFPLLATAYA FQFVGAYMKE TYHRINEGIG QGDLSELPEL HALTAGLKAF TSWTANTGIE ACRMACGGHG YSHCSGLPNI YVNFTPSCTF EGENTVMMLQ TARFLMKSYD QVHSGKLVCG MVSYLNDLPS QRIQPQQVAV WPTMVDINSP ESLTEAYKLR AARLVEIAAK NLQKEVIHRK SKEVAWNLTS VDLVRASEAH CHYVVVKLFS EKLLKIQDKA IQAVLRSLCL LYSLYGISQN AGDFLQGSIM TEPQITQVNQ RVKELLTLIR SDAVALVDAF DFQDVTLGSV LGRYDGNVYE NLFEWAKNSP LNKAEVHESY KHLKSLQSKL
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