About P2Y purinoceptor 6
P2Y purinoceptor 6 (P2RY6) is a protein
from Homo sapiens identified by UniProt accession
Q15077, 328 residues long.
MolForge cross-references it against 0 known binders and
169 disease associations.
Target properties
| Protein name | P2Y purinoceptor 6 |
|---|
| UniProt accession | Q15077 |
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| Gene | P2RY6 |
|---|
| Organism | Homo sapiens |
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| Length | 328 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (169)
Diseases linked to this target (Open Targets).
- dry eye syndrome · score 0.55
- ovarian cancer · score 0.24
- breast adenocarcinoma · score 0.24
- cutaneous melanoma · score 0.13
- low grade glioma · score 0.12
- prostate adenocarcinoma · score 0.10
- basophil count · score 0.09
- neoplasm · score 0.09
- lung adenocarcinoma · score 0.09
- monocyte count · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15077-F1 | alphafold | PREDICTED | 85.94 | — |
Amino-acid sequence (328 residues)
MEWDNGTGQA LGLPPTTCVY RENFKQLLLP PVYSAVLAAG LPLNICVITQ ICTSRRALTR TAVYTLNLAL ADLLYACSLP LLIYNYAQGD HWPFGDFACR LVRFLFYANL HGSILFLTCI SFQRYLGICH PLAPWHKRGG RRAAWLVCVA VWLAVTTQCL PTAIFAATGI QRNRTVCYDL SPPALATHYM PYGMALTVIG FLLPFAALLA CYCLLACRLC RQDGPAEPVA QERRGKAARM AVVVAAAFAI SFLPFHITKT AYLAVRSTPG VPCTVLEAFA AAYKGTRPFA SANSVLDPIL FYFTQKKFRR RPHELLQKLT AKWQRQGR
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