Neutrophil cytosol factor 4 (NCF4)

About Neutrophil cytosol factor 4

Neutrophil cytosol factor 4 (NCF4) is a protein from Homo sapiens identified by UniProt accession Q15080, 339 residues long. MolForge cross-references it against 0 known binders and 179 disease associations.

Target properties

Protein name	Neutrophil cytosol factor 4
UniProt accession	Q15080
Gene	NCF4
Organism	Homo sapiens
Length	339 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (179)

Diseases linked to this target (Open Targets).

chronic granulomatous disease · score 0.65
eosinophil count · score 0.39
eosinophil percentage of leukocytes · score 0.34
multiple sclerosis · score 0.25
asthma · score 0.25
breast adenocarcinoma · score 0.25
Crohn's disease · score 0.24
neutrophil percentage of granulocytes · score 0.24
sum of eosinophil and basophil counts · score 0.24
eosinophil percentage of granulocytes · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15080-F1	alphafold	PREDICTED	84.17	—

Amino-acid sequence (339 residues)

MAVAQQLRAE SDFEQLPDDV AISANIADIE EKRGFTSHFV FVIEVKTKGG SKYLIYRRYR QFHALQSKLE ERFGPDSKSS ALACTLPTLP AKVYVGVKQE IAEMRIPALN AYMKSLLSLP VWVLMDEDVR IFFYQSPYDS EQVPQALRRL RPRTRKVKSV SPQGNSVDRM AAPRAEALFD FTGNSKLELN FKAGDVIFLL SRINKDWLEG TVRGATGIFP LSFVKILKDF PEEDDPTNWL RCYYYEDTIS TIKDIAVEED LSSTPLLKDL LELTRREFQR EDIALNYRDA EGDLVRLLSD EDVALMVRQA RGLPSQKRLF PWKLHITQKD NYRVYNTMP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards