Protein disulfide-isomerase A6 (PDIA6)

About Protein disulfide-isomerase A6

Protein disulfide-isomerase A6 (PDIA6) is a protein from Homo sapiens identified by UniProt accession Q15084, 440 residues long. MolForge cross-references it against 0 known binders and 228 disease associations.

Target properties

Protein name	Protein disulfide-isomerase A6
UniProt accession	Q15084
Gene	PDIA6
Organism	Homo sapiens
Length	440 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (228)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.52
self reported educational attainment · score 0.48
mathematical ability · score 0.42
schizophrenia · score 0.29
intelligence · score 0.29
cognitive function measurement · score 0.28
vital capacity · score 0.27
forced expiratory volume · score 0.09
non-small cell lung carcinoma · score 0.08
oral squamous cell carcinoma · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15084-F1	alphafold	PREDICTED	86.76	—

Amino-acid sequence (440 residues)

MALLVLGLVS CTFFLAVNGL YSSSDDVIEL TPSNFNREVI QSDSLWLVEF YAPWCGHCQR LTPEWKKAAT ALKDVVKVGA VDADKHHSLG GQYGVQGFPT IKIFGSNKNR PEDYQGGRTG EAIVDAALSA LRQLVKDRLG GRSGGYSSGK QGRSDSSSKK DVIELTDDSF DKNVLDSEDV WMVEFYAPWC GHCKNLEPEW AAAASEVKEQ TKGKVKLAAV DATVNQVLAS RYGIRGFPTI KIFQKGESPV DYDGGRTRSD IVSRALDLFS DNAPPPELLE IINEDIAKRT CEEHQLCVVA VLPHILDTGA AGRNSYLEVL LKLADKYKKK MWGWLWTEAG AQSELETALG IGGFGYPAMA AINARKMKFA LLKGSFSEQG INEFLRELSF GRGSTAPVGG GAFPTIVERE PWDGRDGELP VEDDIDLSDV ELDDLGKDEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards