About Platelet-activating factor acetylhydrolase IB subunit alpha1
Platelet-activating factor acetylhydrolase IB subunit alpha1 (PAFAH1B3) is a protein
from Homo sapiens identified by UniProt accession
Q15102, 231 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | Platelet-activating factor acetylhydrolase IB subunit alpha1 |
|---|
| UniProt accession | Q15102 |
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| Gene | PAFAH1B3 |
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| Organism | Homo sapiens |
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| Length | 231 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (71)
Diseases linked to this target (Open Targets).
- autism spectrum disorder · score 0.33
- cancer · score 0.09
- hepatocellular carcinoma · score 0.09
- neoplasm · score 0.08
- lung adenocarcinoma · score 0.08
- appendicular lean mass · score 0.07
- BMI-adjusted waist circumference · score 0.07
- body height · score 0.06
- balding measurement · score 0.06
- non-small cell lung carcinoma · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15102-F1 | alphafold | PREDICTED | 94.80 | — |
Amino-acid sequence (231 residues)
MSGEENPASK PTPVQDVQGD GRWMSLHHRF VADSKDKEPE VVFIGDSLVQ LMHQCEIWRE LFSPLHALNF GIGGDGTQHV LWRLENGELE HIRPKIVVVW VGTNNHGHTA EQVTGGIKAI VQLVNERQPQ ARVVVLGLLP RGQHPNPLRE KNRQVNELVR AALAGHPRAH FLDADPGFVH SDGTISHHDM YDYLHLSRLG YTPVCRALHS LLLRLLAQDQ GQGAPLLEPA P
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