Inactive phospholipase C-like protein 1 (PLCL1)

About Inactive phospholipase C-like protein 1

Inactive phospholipase C-like protein 1 (PLCL1) is a protein from Homo sapiens identified by UniProt accession Q15111, 1095 residues long. MolForge cross-references it against 0 known binders and 174 disease associations.

Target properties

Protein name	Inactive phospholipase C-like protein 1
UniProt accession	Q15111
Gene	PLCL1
Organism	Homo sapiens
Length	1095 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (174)

Diseases linked to this target (Open Targets).

alkaline phosphatase measurement · score 0.42
body height · score 0.41
electrocardiography · score 0.40
mathematical ability · score 0.40
self reported educational attainment · score 0.40
BMI-adjusted waist circumference · score 0.38
body mass index · score 0.38
asthma · score 0.37
allergic rhinitis · score 0.37
chronotype measurement · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15111-F1	alphafold	PREDICTED	81.52	—

Amino-acid sequence (1095 residues)

MAEGAAGRED PAPPDAAGGE DDPRVGPDAA GDCVTAASGG RMRDRRSGVA LPGAAGTPAD SEAGLLEAAR ATPRRSSIIK DPSNQKCGGR KKTVSFSSMP SEKKISSAND CISFMQAGCE LKKVRPNSRI YNRFFTLDTD LQALRWEPSK KDLEKAKLDI SAIKEIRLGK NTETFRNNGL ADQICEDCAF SILHGENYES LDLVANSADV ANIWVSGLRY LVSRSKQPLD FMEGNQNTPR FMWLKTVFEA ADVDGNGIML EDTSVELIKQ LNPTLKEAKI RLKFKEIQKS KEKLTTRVTE EEFCEAFCEL CTRPEVYFLL VQISKNKEYL DANDLMLFLE AEQGVTHITE DICLDIIRRY ELSEEGRQKG FLAIDGFTQY LLSSECDIFD PEQKKVAQDM TQPLSHYYIN ASHNTYLIED QFRGPADING YIRALKMGCR SVELDVSDGS DNEPILCNRN NMTTHVSFRS VIEVINKFAF VASEYPLILC LGNHCSLPQQ KVMAQQMKKV FGNKLYTEAP LPSESYLPSP EKLKRMIIVK GKKLPSDPDV LEGEVTDEDE EAEMSRRMSV DYNGEQKQIR LCRELSDLVS ICKSVQYRDF ELSMKSQNYW EMCSFSETEA SRIANEYPED FVNYNKKFLS RIYPSAMRID SSNLNPQDFW NCGCQIVAMN FQTPGPMMDL HTGWFLQNGG CGYVLRPSIM RDEVSYFSAN TKGILPGVSP LALHIKIISG QNFPKPKGAC AKGDVIDPYV CIEIHGIPAD CSEQRTKTVQ QNSDNPIFDE TFEFQVNLPE LAMIRFVVLD DDYIGDEFIG QYTIPFECLQ PGYRHVPLRS FVGDIMEHVT LFVHIAITNR SGGGKAQKRS LSVRMGKKVR EYTMLRNIGL KTIDDIFKIA VHPLREAIDM RENMQNAIVS IKELCGLPPI ASLKQCLLTL SSRLITSDNT PSVSLVMKDS FPYLEPLGAI PDVQKKMLTA YDLMIQESRF LIEMADTVQE KIVQCQKAGM EFHEELHNLG AKEGLKGRKL NKATESFAWN ITVLKGQGDL LKNAKNEAIE NMKQIQLACL SCGLSKAPSS SAEAKSKRSL EAIEEKESSE ENGKL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards