About Programmed cell death protein 1
Programmed cell death protein 1 (PDCD1) is a protein
from Homo sapiens identified by UniProt accession
Q15116, 288 residues long.
MolForge cross-references it against 0 known binders and
1,299 disease associations.
Target properties
| Protein name | Programmed cell death protein 1 |
|---|
| UniProt accession | Q15116 |
|---|
| Gene | PDCD1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 288 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (9)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (1299)
Diseases linked to this target (Open Targets).
- non-small cell lung carcinoma · score 0.62
- melanoma · score 0.61
- renal cell carcinoma · score 0.60
- neoplasm · score 0.60
- head and neck squamous cell carcinoma · score 0.59
- hepatocellular carcinoma · score 0.59
- breast cancer · score 0.58
- metastatic melanoma · score 0.57
- squamous cell carcinoma · score 0.56
- Hodgkins lymphoma · score 0.56
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15116-F1 | alphafold | PREDICTED | 74.15 | — |
Amino-acid sequence (288 residues)
MQIPQAPWPV VWAVLQLGWR PGWFLDSPDR PWNPPTFSPA LLVVTEGDNA TFTCSFSNTS ESFVLNWYRM SPSNQTDKLA AFPEDRSQPG QDCRFRVTQL PNGRDFHMSV VRARRNDSGT YLCGAISLAP KAQIKESLRA ELRVTERRAE VPTAHPSPSP RPAGQFQTLV VGVVGGLLGS LVLLVWVLAV ICSRAARGTI GARRTGQPLK EDPSAVPVFS VDYGELDFQW REKTPEPPVP CVPEQTEYAT IVFPSGMGTS SPARRGSADG PRSAQPLRPE DGHCSWPL
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