About [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) is a protein
from Homo sapiens identified by UniProt accession
Q15118, 436 residues long.
MolForge cross-references it against 0 known binders and
145 disease associations.
Target properties
| Protein name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial |
|---|
| UniProt accession | Q15118 |
|---|
| Gene | PDK1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 436 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (145)
Diseases linked to this target (Open Targets).
- Crohn's disease · score 0.31
- lactic acidosis · score 0.28
- pyruvate dehydrogenase deficiency · score 0.26
- [Pyruvate dehydrogenase acetyl-transferring] kinase isozyme 1, mitochondrial measurement · score 0.25
- eosinophil count · score 0.22
- antisocial behaviour measurement · score 0.20
- attention deficit hyperactivity disorder · score 0.20
- substance abuse · score 0.20
- glioblastoma multiforme · score 0.10
- neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15118-F1 | alphafold | PREDICTED | 85.94 | — |
Amino-acid sequence (436 residues)
MRLARLLRGA ALAGPGPGLR AAGFSRSFSS DSGSSPASER GVPGQVDFYA RFSPSPLSMK QFLDFGSVNA CEKTSFMFLR QELPVRLANI MKEISLLPDN LLRTPSVQLV QSWYIQSLQE LLDFKDKSAE DAKAIYDFTD TVIRIRNRHN DVIPTMAQGV IEYKESFGVD PVTSQNVQYF LDRFYMSRIS IRMLLNQHSL LFGGKGKGSP SHRKHIGSIN PNCNVLEVIK DGYENARRLC DLYYINSPEL ELEELNAKSP GQPIQVVYVP SHLYHMVFEL FKNAMRATME HHANRGVYPP IQVHVTLGNE DLTVKMSDRG GGVPLRKIDR LFNYMYSTAP RPRVETSRAV PLAGFGYGLP ISRLYAQYFQ GDLKLYSLEG YGTDAVIYIK ALSTDSIERL PVYNKAAWKH YNTNHEADDW CVPSREPKDM TTFRSA
Explore [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets