About [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (PDK2) is a protein
from Homo sapiens identified by UniProt accession
Q15119, 407 residues long.
MolForge cross-references it against 0 known binders and
141 disease associations.
Target properties
| Protein name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial |
|---|
| UniProt accession | Q15119 |
|---|
| Gene | PDK2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 407 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (141)
Diseases linked to this target (Open Targets).
- lactic acidosis · score 0.28
- pyruvate dehydrogenase deficiency · score 0.26
- mathematical ability · score 0.25
- glioblastoma multiforme · score 0.10
- hepatocellular carcinoma · score 0.09
- diabetes mellitus · score 0.08
- head and neck squamous cell carcinoma · score 0.08
- heart disease · score 0.07
- neoplasm · score 0.05
- neuronal ceroid lipofuscinosis 1 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15119-F1 | alphafold | PREDICTED | 90.76 | — |
Amino-acid sequence (407 residues)
MRWVWALLKN ASLAGAPKYI EHFSKFSPSP LSMKQFLDFG SSNACEKTSF TFLRQELPVR LANIMKEINL LPDRVLSTPS VQLVQSWYVQ SLLDIMEFLD KDPEDHRTLS QFTDALVTIR NRHNDVVPTM AQGVLEYKDT YGDDPVSNQN IQYFLDRFYL SRISIRMLIN QHTLIFDGST NPAHPKHIGS IDPNCNVSEV VKDAYDMAKL LCDKYYMASP DLEIQEINAA NSKQPIHMVY VPSHLYHMLF ELFKNAMRAT VESHESSLIL PPIKVMVALG EEDLSIKMSD RGGGVPLRKI ERLFSYMYST APTPQPGTGG TPLAGFGYGL PISRLYAKYF QGDLQLFSME GFGTDAVIYL KALSTDSVER LPVYNKSAWR HYQTIQEAGD WCVPSTEPKN TSTYRVS
Explore [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets