About [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial (PDK3) is a protein
from Homo sapiens identified by UniProt accession
Q15120, 406 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 3, mitochondrial |
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| UniProt accession | Q15120 |
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| Gene | PDK3 |
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| Organism | Homo sapiens |
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| Length | 406 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (71)
Diseases linked to this target (Open Targets).
- Charcot-Marie-Tooth disease X-linked dominant 6 · score 0.61
- X-linked Charcot-Marie-Tooth disease type 6 · score 0.46
- lactic acidosis · score 0.28
- pyruvate dehydrogenase deficiency · score 0.26
- Charcot-Marie-Tooth disease · score 0.17
- pyruvate measurement · score 0.11
- glioblastoma multiforme · score 0.10
- head and neck squamous cell carcinoma · score 0.08
- heart disease · score 0.07
- neoplasm · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15120-F1 | alphafold | PREDICTED | 91.42 | — |
Amino-acid sequence (406 residues)
MRLFRWLLKQ PVPKQIERYS RFSPSPLSIK QFLDFGRDNA CEKTSYMFLR KELPVRLANT MREVNLLPDN LLNRPSVGLV QSWYMQSFLE LLEYENKSPE DPQVLDNFLQ VLIKVRNRHN DVVPTMAQGV IEYKEKFGFD PFISTNIQYF LDRFYTNRIS FRMLINQHTL LFGGDTNPVH PKHIGSIDPT CNVADVVKDA YETAKMLCEQ YYLVAPELEV EEFNAKAPDK PIQVVYVPSH LFHMLFELFK NSMRATVELY EDRKEGYPAV KTLVTLGKED LSIKISDLGG GVPLRKIDRL FNYMYSTAPR PSLEPTRAAP LAGFGYGLPI SRLYARYFQG DLKLYSMEGV GTDAVIYLKA LSSESFERLP VFNKSAWRHY KTTPEADDWS NPSSEPRDAS KYKAKQ
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