Astrocytic phosphoprotein PEA-15 (PEA15)

About Astrocytic phosphoprotein PEA-15

Astrocytic phosphoprotein PEA-15 (PEA15) is a protein from Homo sapiens identified by UniProt accession Q15121, 130 residues long. MolForge cross-references it against 0 known binders and 79 disease associations.

Target properties

Protein name	Astrocytic phosphoprotein PEA-15
UniProt accession	Q15121
Gene	PEA15
Organism	Homo sapiens
Length	130 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (79)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.10
polycystic ovary syndrome · score 0.06
neoplasm · score 0.06
FEV/FVC ratio · score 0.05
triple-negative breast cancer · score 0.05
glioblastoma · score 0.04
colorectal carcinoma · score 0.03
malignant pleural mesothelioma · score 0.03
type 2 diabetes mellitus · score 0.03
neuroblastoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15121-F1	alphafold	PREDICTED	77.95	—

Amino-acid sequence (130 residues)

MAEYGTLLQD LTNNITLEDL EQLKSACKED IPSEKSEEIT TGSAWFSFLE SHNKLDKDNL SYIEHIFEIS RRPDLLTMVV DYRTRVLKIS EEDELDTKLT RIPSAKKYKD IIRQPSEEEI IKLAPPPKKA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards