About Phosphomevalonate kinase
Phosphomevalonate kinase (PMVK) is a protein
from Homo sapiens identified by UniProt accession
Q15126, 192 residues long.
MolForge cross-references it against 0 known binders and
53 disease associations.
Target properties
| Protein name | Phosphomevalonate kinase |
|---|
| UniProt accession | Q15126 |
|---|
| Gene | PMVK |
|---|
| Organism | Homo sapiens |
|---|
| Length | 192 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (53)
Diseases linked to this target (Open Targets).
- porokeratosis 1, Mibelli type · score 0.54
- neurodegenerative disease · score 0.53
- linear porokeratosis · score 0.40
- porokeratosis of Mibelli · score 0.37
- genetic disorder · score 0.18
- prostate carcinoma · score 0.16
- atrial fibrillation · score 0.13
- PHF-tau measurement · score 0.13
- FEV/FVC ratio · score 0.12
- drug use measurement · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15126-F1 | alphafold | PREDICTED | 92.36 | — |
Amino-acid sequence (192 residues)
MAPLGGAPRL VLLFSGKRKS GKDFVTEALQ SRLGADVCAV LRLSGPLKEQ YAQEHGLNFQ RLLDTSTYKE AFRKDMIRWG EEKRQADPGF FCRKIVEGIS QPIWLVSDTR RVSDIQWFRE AYGAVTQTVR VVALEQSRQQ RGWVFTPGVD DAESECGLDN FGDFDWVIEN HGVEQRLEEQ LENLIEFIRS RL
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