Cyclin-dependent kinase 10 (CDK10)

About Cyclin-dependent kinase 10

Cyclin-dependent kinase 10 (CDK10) is a protein from Homo sapiens identified by UniProt accession Q15131, 360 residues long. MolForge cross-references it against 0 known binders and 153 disease associations.

Target properties

Protein name	Cyclin-dependent kinase 10
UniProt accession	Q15131
Gene	CDK10
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (153)

Diseases linked to this target (Open Targets).

Al Kaissi syndrome · score 0.72
neurodegenerative disease · score 0.53
genetic disorder · score 0.45
Intellectual disability · score 0.37
Global developmental delay · score 0.34
Abnormal brain morphology · score 0.33
blood protein measurement · score 0.18
melanoma · score 0.14
mitochondrial DNA measurement · score 0.13
body height · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15131-F1	alphafold	PREDICTED	85.94	—

Amino-acid sequence (360 residues)

MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAT SEGQSKRCKP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards