Serum paraoxonase/lactonase 3 (PON3)

About Serum paraoxonase/lactonase 3

Serum paraoxonase/lactonase 3 (PON3) is a protein from Homo sapiens identified by UniProt accession Q15166, 354 residues long. MolForge cross-references it against 0 known binders and 160 disease associations.

Target properties

Protein name	Serum paraoxonase/lactonase 3
UniProt accession	Q15166
Gene	PON3
Organism	Homo sapiens
Length	354 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (160)

Diseases linked to this target (Open Targets).

amyotrophic lateral sclerosis · score 0.37
Amyotrophic lateral sclerosis · score 0.37
blood protein measurement · score 0.33
high density lipoprotein cholesterol measurement · score 0.24
head and neck squamous cell carcinoma · score 0.11
neoplasm · score 0.09
hepatocellular carcinoma · score 0.09
hypertriglyceridemia 2 · score 0.06
cholesterol-ester transfer protein deficiency · score 0.05
neonatal intrahepatic cholestasis due to citrin deficiency · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q15166-F1	alphafold	PREDICTED	96.32	—

Amino-acid sequence (354 residues)

MGKLVALVLL GVGLSLVGEM FLAFRERVNA SREVEPVEPE NCHLIEELES GSEDIDILPS GLAFISSGLK YPGMPNFAPD EPGKIFLMDL NEQNPRAQAL EISGGFDKEL FNPHGISIFI DKDNTVYLYV VNHPHMKSTV EIFKFEEQQR SLVYLKTIKH ELLKSVNDIV VLGPEQFYAT RDHYFTNSLL SFFEMILDLR WTYVLFYSPR EVKVVAKGFC SANGITVSAD QKYVYVADVA AKNIHIMEKH DNWDLTQLKV IQLGTLVDNL TVDPATGDIL AGCHPNPMKL LNYNPEDPPG SEVLRIQNVL SEKPRVSTVY ANNGSVLQGT SVASVYHGKI LIGTVFHKTL YCEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards