About Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform (PPP2R5A) is a protein
from Homo sapiens identified by UniProt accession
Q15172, 486 residues long.
MolForge cross-references it against 0 known binders and
111 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform |
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| UniProt accession | Q15172 |
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| Gene | PPP2R5A |
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| Organism | Homo sapiens |
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| Length | 486 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (111)
Diseases linked to this target (Open Targets).
- cancer · score 0.53
- basophil count · score 0.40
- BMI-adjusted waist-hip ratio · score 0.40
- mean corpuscular volume · score 0.38
- high density lipoprotein cholesterol measurement · score 0.38
- chronic myelogenous leukemia · score 0.37
- body height · score 0.37
- Red cell distribution width · score 0.37
- lymphocyte count · score 0.36
- neurodegenerative disease · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15172-F1 | alphafold | PREDICTED | 88.39 | — |
Amino-acid sequence (486 residues)
MSSSSPPAGA ASAAISASEK VDGFTRKSVR KAQRQKRSQG SSQFRSQGSQ AELHPLPQLK DATSNEQQEL FCQKLQQCCI LFDFMDSVSD LKSKEIKRAT LNELVEYVST NRGVIVESAY SDIVKMISAN IFRTLPPSDN PDFDPEEDEP TLEASWPHIQ LVYEFFLRFL ESPDFQPSIA KRYIDQKFVQ QLLELFDSED PRERDFLKTV LHRIYGKFLG LRAFIRKQIN NIFLRFIYET EHFNGVAELL EILGSIINGF ALPLKAEHKQ FLMKVLIPMH TAKGLALFHA QLAYCVVQFL EKDTTLTEPV IRGLLKFWPK TCSQKEVMFL GEIEEILDVI EPTQFKKIEE PLFKQISKCV SSSHFQVAER ALYFWNNEYI LSLIEENIDK ILPIMFASLY KISKEHWNPT IVALVYNVLK TLMEMNGKLF DDLTSSYKAE RQREKKKELE REELWKKLEE LKLKKALEKQ NSAYNMHSIL SNTSAE
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