About Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform (PPP2R5B) is a protein
from Homo sapiens identified by UniProt accession
Q15173, 497 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform |
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| UniProt accession | Q15173 |
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| Gene | PPP2R5B |
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| Organism | Homo sapiens |
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| Length | 497 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- cancer · score 0.53
- neurodegenerative disease · score 0.50
- chronic myelogenous leukemia · score 0.37
- glioblastoma multiforme · score 0.30
- breast adenocarcinoma · score 0.29
- endometrial cancer · score 0.29
- neuroinflammatory disorder · score 0.29
- lung adenocarcinoma · score 0.28
- ovarian cancer · score 0.28
- cutaneous melanoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15173-F1 | alphafold | PREDICTED | 86.05 | — |
Amino-acid sequence (497 residues)
METKLPPAST PTSPSSPGLS PVPPPDKVDG FSRRSLRRAR PRRSHSSSQF RYQSNQQELT PLPLLKDVPA SELHELLSRK LAQCGVMFDF LDCVADLKGK EVKRAALNEL VECVGSTRGV LIEPVYPDII RMISVNIFRT LPPSENPEFD PEEDEPNLEP SWPHLQLVYE FFLRFLESPD FQPSVAKRYV DQKFVLMLLE LFDSEDPRER EYLKTILHRV YGKFLGLRAY IRKQCNHIFL RFIYEFEHFN GVAELLEILG SIINGFALPL KTEHKQFLVR VLIPLHSVKS LSVFHAQLAY CVVQFLEKDA TLTEHVIRGL LKYWPKTCTQ KEVMFLGEME EILDVIEPSQ FVKIQEPLFK QVARCVSSPH FQVAERALYF WNNEYILSLI EDNCHTVLPA VFGTLYQVSK EHWNQTIVSL IYNVLKTFME MNGKLFDELT ASYKLEKQQE QQKAQERQEL WQGLEELRLR RLQGTQGAKE APLQRLTPQV AASGGQS
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