About Inorganic pyrophosphatase
Inorganic pyrophosphatase (PPA1) is a protein
from Homo sapiens identified by UniProt accession
Q15181, 289 residues long.
MolForge cross-references it against 0 known binders and
72 disease associations.
Target properties
| Protein name | Inorganic pyrophosphatase |
|---|
| UniProt accession | Q15181 |
|---|
| Gene | PPA1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 289 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (72)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- erythrocyte count · score 0.24
- aspartate aminotransferase measurement · score 0.23
- neuroinflammatory disorder · score 0.19
- inorganic pyrophosphatase measurement · score 0.16
- neoplasm · score 0.11
- non-small cell lung carcinoma · score 0.08
- PHF-tau measurement · score 0.05
- cancer · score 0.03
- body height · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15181-F1 | alphafold | PREDICTED | 96.17 | — |
Amino-acid sequence (289 residues)
MSGFSTEERA APFSLEYRVF LKNEKGQYIS PFHDIPIYAD KDVFHMVVEV PRWSNAKMEI ATKDPLNPIK QDVKKGKLRY VANLFPYKGY IWNYGAIPQT WEDPGHNDKH TGCCGDNDPI DVCEIGSKVC ARGEIIGVKV LGILAMIDEG ETDWKVIAIN VDDPDAANYN DINDVKRLKP GYLEATVDWF RRYKVPDGKP ENEFAFNAEF KDKDFAIDII KSTHDHWKAL VTKKTNGKGI SCMNTTLSES PFKCDPDAAR AIVDALPPPC ESACTVPTDV DKWFHHQKN
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