About Prostaglandin E synthase 3
Prostaglandin E synthase 3 (PTGES3) is a protein
from Homo sapiens identified by UniProt accession
Q15185, 160 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Prostaglandin E synthase 3 |
|---|
| UniProt accession | Q15185 |
|---|
| Gene | PTGES3 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 160 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.55
- mean platelet volume · score 0.28
- serum alanine aminotransferase measurement · score 0.23
- platelet count · score 0.21
- aspartate aminotransferase measurement · score 0.19
- breast adenocarcinoma · score 0.18
- heel bone mineral density · score 0.15
- electrocardiography · score 0.15
- head and neck squamous cell carcinoma · score 0.13
- platelet component distribution width · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15185-F1 | alphafold | PREDICTED | 85.44 | — |
Amino-acid sequence (160 residues)
MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE
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