About Non-POU domain-containing octamer-binding protein
Non-POU domain-containing octamer-binding protein (NONO) is a protein
from Homo sapiens identified by UniProt accession
Q15233, 471 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | Non-POU domain-containing octamer-binding protein |
|---|
| UniProt accession | Q15233 |
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| Gene | NONO |
|---|
| Organism | Homo sapiens |
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| Length | 471 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (152)
Diseases linked to this target (Open Targets).
- syndromic X-linked intellectual disability 34 · score 0.74
- syndromic intellectual disability · score 0.55
- genetic disorder · score 0.46
- X-linked syndromic intellectual disability · score 0.37
- Neurodevelopmental delay · score 0.34
- renal carcinoma · score 0.28
- congenital heart disease · score 0.27
- Abnormal heart morphology · score 0.27
- melanoma · score 0.19
- Renal Cell Carcinoma Associated with Xp11.2 Translocations/TFE3 Gene Fusions · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15233-F1 | alphafold | PREDICTED | 76.76 | — |
Amino-acid sequence (471 residues)
MQSNKTFNLE KQNHTPRKHH QHHHQQQHHQ QQQQQPPPPP IPANGQQASS QNEGLTIDLK NFRKPGEKTF TQRSRLFVGN LPPDITEEEM RKLFEKYGKA GEVFIHKDKG FGFIRLETRT LAEIAKVELD NMPLRGKQLR VRFACHSASL TVRNLPQYVS NELLEEAFSV FGQVERAVVI VDDRGRPSGK GIVEFSGKPA ARKALDRCSE GSFLLTTFPR PVTVEPMDQL DDEEGLPEKL VIKNQQFHKE REQPPRFAQP GSFEYEYAMR WKALIEMEKQ QQDQVDRNIK EAREKLEMEM EAARHEHQVM LMRQDLMRRQ EELRRMEELH NQEVQKRKQL ELRQEEERRR REEEMRRQQE EMMRRQQEGF KGTFPDAREQ EIRMGQMAMG GAMGINNRGA MPPAPVPAGT PAPPGPATMM PDGTLGLTPP TTERFGQAAT MEGIGAIGGT PPAFNRAAPG AEFAPNKRRR Y
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