About Receptor-type tyrosine-protein phosphatase R
Receptor-type tyrosine-protein phosphatase R (PTPRR) is a protein
from Homo sapiens identified by UniProt accession
Q15256, 657 residues long.
MolForge cross-references it against 0 known binders and
152 disease associations.
Target properties
| Protein name | Receptor-type tyrosine-protein phosphatase R |
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| UniProt accession | Q15256 |
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| Gene | PTPRR |
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| Organism | Homo sapiens |
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| Length | 657 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (152)
Diseases linked to this target (Open Targets).
- refractive error · score 0.43
- Abnormality of refraction · score 0.40
- apolipoprotein A 1 measurement · score 0.36
- neurodegenerative disease · score 0.33
- Myopia · score 0.32
- age at onset · score 0.32
- aspartate aminotransferase measurement · score 0.30
- uterine fibroid · score 0.30
- type 1 diabetes mellitus · score 0.25
- high density lipoprotein cholesterol measurement · score 0.24
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15256-F1 | alphafold | PREDICTED | 72.24 | — |
Amino-acid sequence (657 residues)
MRRAVCFPAL CLLLNLHAAG CFSGNNDHFL AINQKKSGKP VFIYKHSQDI EKSLDIAPQK IYRHSYHSSS EAQVSKRHQI VNSAFPRPAY DPSLNLLAMD GQDLEVENLP IPAANVIVVT LQMDVNKLNI TLLRIFRQGV AAALGLLPQQ VHINRLIGKK NSIELFVSPI NRKTGISDAL PSEEVLRSLN INVLHQSLSQ FGITEVSPEK NVLQGQHEAD KIWSKEGFYA VVIFLSIFVI IVTCLMILYR LKERFQLSLR QDKEKNQEIH LSPITLQPAL SEAKTVHSMV QPEQAPKVLN VVVDPQGRGA PEIKATTATS VCPSPFKMKP IGLQERRGSN VSLTLDMSSL GNIEPFVSIP TPREKVAMEY LQSASRILTR SQLRDVVASS HLLQSEFMEI PMNFVDPKEI DIPRHGTKNR YKTILPNPLS RVCLRPKNVT DSLSTYINAN YIRGYSGKEK AFIATQGPMI NTVDDFWQMV WQEDSPVIVM ITKLKEKNEK CVLYWPEKRG IYGKVEVLVI SVNECDNYTI RNLVLKQGSH TQHVKHYWYT SWPDHKTPDS AQPLLQLMLD VEEDRLASQG RGPVVVHCSA GIGRTGCFIA TSIGCQQLKE EGVVDALSIV CQLRMDRGGM VQTSEQYEFV HHALCLYESR LSAETVQ
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