About Serine/threonine-protein phosphatase 2A activator
Serine/threonine-protein phosphatase 2A activator (PTPA) is a protein
from Homo sapiens identified by UniProt accession
Q15257, 358 residues long.
MolForge cross-references it against 0 known binders and
412 disease associations.
Target properties
| Protein name | Serine/threonine-protein phosphatase 2A activator |
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| UniProt accession | Q15257 |
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| Gene | PTPA |
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| Organism | Homo sapiens |
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| Length | 358 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (412)
Diseases linked to this target (Open Targets).
- parkinson disease 25, autosomal recessive early-onset, with impaired intellectual development · score 0.51
- blood metabolite measurement · score 0.36
- Red cell distribution width · score 0.36
- hemoglobin measurement · score 0.30
- cerebellar volume measurement · score 0.30
- urinary metabolite measurement · score 0.27
- red blood cell density measurement · score 0.25
- HbA1c measurement · score 0.24
- cognitive function measurement · score 0.24
- balding measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15257-F1 | alphafold | PREDICTED | 87.20 | — |
Amino-acid sequence (358 residues)
MAEGERQPPP DSSEEAPPAT QNFIIPKKEI HTVPDMGKWK RSQAYADYIG FILTLNEGVK GKKLTFEYRV SEMWNEVHEE KEQAAKQSVS CDECIPLPRA GHCAPSEAIE KLVALLNTLD RWIDETPPVD QPSRFGNKAY RTWYAKLDEE AENLVATVVP THLAAAVPEV AVYLKESVGN STRIDYGTGH EAAFAAFLCC LCKIGVLRVD DQIAIVFKVF NRYLEVMRKL QKTYRMEPAG SQGVWGLDDF QFLPFIWGSS QLIDHPYLEP RHFVDEKAVN ENHKDYMFLE CILFITEMKT GPFAEHSNQL WNISAVPSWS KVNQGLIRMY KAECLEKFPV IQHFKFGSLL PIHPVTSG
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