About NK1 transcription factor-related protein 1
NK1 transcription factor-related protein 1 (NKX1-1) is a protein
from Homo sapiens identified by UniProt accession
Q15270, 448 residues long.
MolForge cross-references it against 0 known binders and
9 disease associations.
Target properties
| Protein name | NK1 transcription factor-related protein 1 |
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| UniProt accession | Q15270 |
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| Gene | NKX1-1 |
|---|
| Organism | Homo sapiens |
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| Length | 448 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (9)
Diseases linked to this target (Open Targets).
- neurofibrillary tangles measurement · score 0.14
- substance abuse · score 0.10
- antisocial behaviour measurement · score 0.10
- attention deficit hyperactivity disorder · score 0.10
- heel bone mineral density · score 0.07
- refractive error measurement · score 0.03
- vital capacity · score 0.03
- forced expiratory volume · score 0.02
- Insulin resistance · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q15270-F1 | alphafold | PREDICTED | 58.34 | — |
Amino-acid sequence (448 residues)
MSASGPEAPG DIPALPPPPQ PGSGPAPPAP AAAAQEAMDG RAELPAFPRA GAPPLAASDT VPAAPEGAGA ARPAAPLRPT SFSVLDILDP NKFNSRRRRC VLLGPVAPAA CAPCASAPCA PAPAASGRPP RAEELERRAL AGAGGVGAAG AEPPNAGDPF KAGEAETNDT NGYSSGGGGH SPSADSGDEV PDDEDDDEDE APETEAARGA EEARGGGGGL GARGSGCQGA AETDASPGAT VDEAAAPGPR ENSPVAQGPP GGAAAPGGAG TTPQGTATAA KPKRKRTGSD SKSGKPRRAR TAFTYEQLVA LENKFKATRY LSVCERLNLA LSLSLTETQV KIWFQNRRTK WKKQNPGADT SAPTGGGGGP GPGAGPGTGL PGGLSPLSPS PPMGAPLGMH GPAGYPAHGP GGLVCAAQLP FLSSPAVLSP FVLGSQTYGA PAFYAPHL
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